中文

2024-01-16

前沿速览010期| CAR-T治B淋 前沿览新知


01

表达诱导性 IL-7 和 CCL19 的抗 CD19 CAR-T 细胞治疗复发或难治性大 B 细胞淋巴瘤患者的安全性和可行性

Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma


第一作者:Lei W


Cell Discov (IF=33.5). 2024 Jan 9;10(1):5. 


全文网址:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774422/

02

复发/难治性滤泡性淋巴瘤成人患者接受Tisagenlecleucel治疗后获得持久缓解:ELARA试验更新

Durable Response After Tisagenlecleucel in Adults With Relapsed/Refractory Follicular Lymphoma: ELARA Trial Update


第一作者:Dreyling M


Blood (IF=20.3). 2024 Jan 9:blood.2023021567.


全文网址:https://ashpublications.org/blood/article/doi/10.1182/blood.2023021567/507096/Durable-Response-After-Tisagenlecleucel-in-Adults

03

CAR-T 细胞疗法的安全性改善:接受 CAR-T 细胞疗法的复发性或难治性 B 细胞淋巴瘤患者的病毒感染风险与预防

Improving the safety of CAR-T-cell therapy: The risk and prevention of viral infection for patients with relapsed or refractory B-cell lymphoma undergoing CAR-T-cell therapy


第一作者:Qian H


Am J Hematol (IF=12.8). 2024 Jan 10. 


全文网址https://onlinelibrary.wiley.com/doi/10.1002/ajh.27198

04

基线血清炎症蛋白可预测CAR-T 治疗弥漫大 B 细胞淋巴瘤的不良预后

Baseline serum inflammatory proteins predict poor CAR T outcomes in diffuse large B-cell lymphoma


第一作者:Faramand RG


Blood Cancer Discov (IF=11.2). 2024 Jan 9. 


全文网址:https://aacrjournals.org/bloodcancerdiscov/article/doi/10.1158/2643-3230.BCD-23-0056/732968/Baseline-serum-inflammatory-proteins-predict-poor

05

CAR-T 细胞治疗大 B 细胞淋巴瘤后的输血需求:预测因素和结局 (DESCAR-T研究)

Transfusion needs after CAR T-cell therapy for large B-cell lymphoma: predictive factors and outcome. A DESCAR-T study


第一作者:Vic S


Blood Adv (IF=7.6). 2024 Jan 4:bloodadvances.2023011727. 


全文网址:https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2023011727/506969/Transfusion-needs-after-CAR-T-cell-therapy-for

06

在实验鼠模型中比较治疗恶性血液病的抗体免疫疗法

Comparison of antibody-based immunotherapeutics for malignant hematological disease in an experimental murine model


第一作者:Albring JC


Blood Adv (IF=7.6). 2024 Jan 10:bloodadvances.2023011647. 


全文网址:https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2023011647/507107/Comparison-of-antibody-based-immunotherapeutics

07

清淋-CAR-T 细胞治疗全流程中至关重要但被低估的部分

Lymphodepletion - an essential but undervalued part of the chimeric antigen receptor T-cell therapy cycle


第一作者:Lickefett B


Front Immunol (IF=7.3). 2023 Dec 22;14:1303935. 


全文网址:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10770848/

08

合并干燥综合症的弥漫性大 B 细胞淋巴瘤患者接受抗 CD19 CAR-T细胞治疗后,淋巴瘤和干燥综合症同时得到缓解:病例报告

Concurrent remission of lymphoma and Sjögren's disease following anti-CD19 chimeric antigen receptor-T cell therapy for diffuse large B-cell lymphoma: a case report

第一作者:Sheng L


Front Immunol (IF=7.3). 2023 Dec 19;14:1298815. 


全文网址:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10762793/

09

CAR-T细胞治疗淋巴瘤:新的应用场景与未来方向

Chimeric Antigen Receptor-T Cell Therapy for Lymphoma: New Settings and Future Directions


第一作者:Benevolo Savelli C


Cancers (Basel) (IF=5.2). 2023 Dec 21;16(1):46. 


全文网址:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10778255/

10

接受Axicabtagene ciloleucel和预防性皮质类固醇治疗的大B细胞淋巴瘤患者的长期结局

Long-term outcomes of patients with large B-cell lymphoma treated with axicabtagene ciloleucel and prophylactic corticosteroids


第一作者:Oluwole OO


Bone Marrow Transplant (IF=4.8). 2024 Jan 4. 


全文网址:https://www.nature.com/articles/s41409-023-02169-z


免责声明:本资料为专业医学资料,旨在促进医药信息的沟通和交流,仅供医疗卫生专业人士参考;任何处方请参考产品最新详细处方资料。本文件可能包含涉及医学情况、健康及治疗方法的信息。相关信息不得用作诊断或治疗,不能替代专业医学意见。


审批编号:NP-NHL-2024.1-16 valid until 2026.1


供稿与审核:临床开发与医学部